Ocemida NAD+ Cellular Renewal Complex
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NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme present in every cell of your body. It serves as a critical cofactor for sirtuins, the "longevity enzymes" that regulate metabolism, DNA repair, and cellular stress responses. Research shows NAD+ levels decline significantly with age, falling to roughly half of youthful levels by middle age. This formula combines NAD+ with two clinically studied sirtuin activators to support your body's cellular energy production and healthy aging pathways.
The Science of NAD+ Decline
NAD+ has been observed to decrease in human liver, skin, brain, plasma, skeletal muscle, and immune cells with advancing age. Chronically low NAD+ has been linked to accelerated aging and age-related conditions. Our formula provides NAD+ alongside quercetin and resveratrol, both identified as sirtuin-activating compounds that may help optimize NAD+-dependent enzyme function.
Cellular Energy
NAD+ is essential for converting nutrients into cellular energy (ATP)
Sirtuin Activation
Provides the co-substrate sirtuins require to function
DNA Support
NAD+ is consumed by PARP enzymes during DNA repair processes
Healthy Aging
Supports mitochondrial function and metabolic health
Clinically Studied Ingredients
NAD+ (Nicotinamide Adenine Dinucleotide)
500mgA multicenter, randomized, double-blind, placebo-controlled clinical trial with 80 healthy middle-aged adults found that NAD+ precursor supplementation significantly increased blood NAD+ concentrations at day 30 and day 60 compared to both placebo and baseline (p≤0.001). Biological age markers stayed unchanged in treated groups while increasing in the placebo group (p<0.05). Supplementation was safe and well-tolerated with no adverse effects reported.
Strong Clinical EvidenceQuercetin Dihydrate
250mgA meta-analysis published in the Journal of the American Heart Association analyzing 7 randomized controlled trials (587 patients) found quercetin supplementation significantly reduced systolic blood pressure by 3.04 mmHg (p=0.028) and diastolic blood pressure by 2.63 mmHg (p<0.001). Quercetin was identified alongside resveratrol as a sirtuin-activating compound in landmark 2003 research. It has also been shown to inhibit CD38, an enzyme that depletes NAD+ stores.
Strong Clinical EvidenceJapanese Knotweed Extract (98% Resveratrol)
150mgA meta-analysis of 17 randomized controlled trials found resveratrol significantly improved flow-mediated dilation (FMD), a marker of endothelial function (+1.43%, p<0.001). In a 30-day RCT with 48 healthy adults aged 55-65, resveratrol significantly increased circulating SIRT1 levels (p<0.001) and reduced sympathetic nervous system activity. Additional meta-analyses in cardiovascular disease patients show significant reductions in TNF-alpha inflammatory markers (p=0.0005).
Strong Clinical Evidence🔗 The Synergy Advantage: Fuel + Activators
This formula is designed around the NAD+/SIRT1 longevity axis, combining complementary mechanisms:
- NAD+ provides the fuel that sirtuins require as a co-substrate for enzymatic activity
- Quercetin inhibits CD38, an enzyme that depletes NAD+ stores, while also activating SIRT1
- Resveratrol activates SIRT1 by lowering the enzyme's binding affinity for substrates, increasing activity up to 10-fold in laboratory studies
Suggested Use
As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6oz (177ml) of water or as directed by a healthcare professional. Do not exceed recommended dose.
Yi L, et al. (2023). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled clinical trial. GeroScience. PMID: 36482258
Covarrubias AJ, et al. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. PMID: 33353981
Quercetin Blood Pressure:
Serban MC, et al. (2016). Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. PMID: 27405810
Quercetin as Sirtuin Activator/CD38 Inhibitor:
Howitz KT, et al. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. PMID: 12939617
Sharma A, et al. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. PMID: 36678323
Resveratrol Endothelial Function:
Mohammadipoor N, et al. (2022). Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. PMID: 35833325
Resveratrol SIRT1 Activation:
Bonkowski MS, Sinclair DA. (2016). Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. PMID: 27552971
Resveratrol Anti-Inflammatory:
Damay VP, et al. (2024). Resveratrol as an Anti-inflammatory Agent in Coronary Artery Disease: A Systematic Review, Meta-Analysis and Meta-Regression. PMID: 38958883
Ingredients: NAD+ (Nicotinamide Adenine Dinucleotide) (500 mg), Quercetin Dihydrate Extract (Sophora japonica) (whole flower bud) (250 mg), Japanese Knotweed Extract (98% Resveratrol) (Polygonum cuspidatum) (root) (150 mg), HPMC (vegetable capsule), Microcrystalline Cellulose (MCC), Brown Rice Flour, Olive Oil, Silicon Dioxide, Magnesium Stearate.
Manufacturer's country: USA
Product amount: 60 capsules / 1.8 oz / 0.11 lb / 50 g
Gross weight (oz/lb/g): 2.4 oz / 0.15 lb / 68 g
Suggested use: As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6oz (177ml) of water or as directed by healthcare professional.
Warning: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
