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THE SCIENTISTS

Molecular hydrogen scientists have paved the way for innovative products like Ocemida. Their groundbreaking research has revealed the therapeutic potential of hydrogen, leading to the development of our H2-based solutions. These products harness the power of hydrogen to support overall health and well-being. Without the decades of dedication and scientific breakthroughs by these pioneers, Ocemida's innovative line would not exist. Their work has laid the foundation for a new era of preventive and therapeutic medicine

  • Dr. Tyler W. LeBaron, MSc., PhD.
    Molecular Hydrogen Institute

  • Prof. Mami Noda, PhD.
    Institute of Mitochondrial Biology and Medicine of Xi’an Jiaotong University

  • Prof. Xuemei Ma, PhD.
    Beijing University of Technology, College of life science and bioengineering

  • Prof. Sergej M. Ostojic, MD, PhD
    Professor of Biomedical Sciences, University of Novi Sad

  • Prof. Shigeo Ohta, PhD.
    International Molecular Hydrogen Association

  • Prof. Qianjun He, PhD.
    Shanghai Jiao Tong University (SJTU)

  • Prof. Jiangang Long, PhD.
    Center for Mitochondrial Biology and Medicine

  • Prof Masaru Suzuki, MD., PhD.
    Appointment Professor of The Center for Molecular Hydrogen Medicine, Keio University

  • Prof. Eugene Iv. Nazarov, MSc., PhD.
    Steering Committee of the International Association of Medical Gas Therapists

  • Branislav Kura, RNDr., Ph.D.
    Institute for Heart Research,Centre of Experimental Medicine,Slovak Academy of Sciences

  • Dr. Gagandeep Dhillon, MD
    University of Maryland, Baltimore Washington Medical Center

  • Dr. Garth L. Nicolson, PhD, MD (H)
    The Institute for Molecular Medicine

  • Dr. Olga Pol, PhD.
    Molecular Neuropharmacology Group, Sant Pau Research Institute

  • Prof. Dr. Shaoqing Yu, PhD.
    Department of Otolaryngology, Tongji Hospital

  • Grace Russell, MSc., PhD.
    University of the West of England

  • Prof. Oleg S. Medvedev, MD, PhD
    Department of Pharmacology, Lomonosov Moscow State University

  • Barbora Kaločayová, PhD.
    Centre of Experimental Medicine, Slovak Academy of Sciences

  • Prof. SvetlanaN. Radyuk, PhD.
    Department of Biological Sciences, Southern Methodist University

  • Dr. Seyedeh Elnaz Nazari, PhD.
    Mashhad University of Medical Sciences

  • Malte Ostendarp, PhD Candidate
    University of Bremen

  • Jiayuan Zhai, PhD Student
    Harbin Medical University

  • Dejan Javorac, MSc.
    University of Novi Sad

  • Yuxi Wei, MSc (candidate)
    University of British Columbia

  • Nikola Todorović, Msc.
    University of Novi Sad

THE SCIENCE

Molecular hydrogen, the simplest and most abundant element in the universe, is undergoing a renaissance in scientific research that would make even the most jaded chemist's electrons jump with excitement. This diatomic dynamo, composed of two protons hugging a pair of electrons, is not content with its starring role in stellar fusion or as the backbone of organic chemistry. No, H2 has decided to moonlight as a therapeutic agent, slipping through cellular membranes like a quantum ghost and potentially wreaking havoc on oxidative stress. Its diminutive size belies its outsized impact, as it pirouettes through the body, selectively neutralizing harmful free radicals while leaving beneficial ones untouched – a molecular Robin Hood of sorts. The plot thickens as researchers unravel hydrogen's cellular soap opera, where it plays supporting roles in gene expression, cell signaling, and even the gut microbiome's complex ecosystem. As scientists dive deeper into hydrogen's biological exploits, they're finding that this elemental Houdini may hold the key to unlocking new paradigms in medicine, challenging our understanding of how something so simple could be so surprisingly sophisticated.

Molecular hydrogen (H2) interacts with the body's cells in several key ways:

Cellular Penetration

H2 can easily penetrate cell membranes and diffuse into various cellular compartments due to its small size and neutral charge.It rapidly reaches the cytosol, nucleus, and mitochondria within minutes of administration.

Antioxidant Effects

One of H2's primary mechanisms is as a selective antioxidant:

  • It directly scavenges highly reactive oxygen species (ROS) like hydroxyl radicals and peroxynitrite.
  • It inhibits the production of mitochondrial ROS.
  • It enhances the body's antioxidant systems by increasing antioxidant enzymes like superoxide dismutase and catalase.

Gene Expression and Signaling

H2 modulates various cellular signaling pathways and gene expression:

  • It activates the Nrf2 antioxidant pathway, promoting expression of cytoprotective genes.
  • It regulates expression of genes related to metabolism, cell survival, and inflammation.
  • It influences protein phosphorylation cascades involved in cell signaling.

Mitochondrial Function

H2 appears to have significant effects on mitochondria:

  • It promotes mitochondrial biogenesis 1.
  • It activates mitochondrial unfolded protein response pathways 1.
  • It may interact with mitochondrial proteins containing iron-sulfur clusters 2.

Anti-Inflammatory Effects

H2 reduces inflammation by:

  • Decreasing pro-inflammatory cytokines like TNF-α and IL-6.
  • Modulating immune cell function and inflammatory signaling pathways.

Metabolic Regulation

H2 influences cellular metabolism:

  • It affects lipid and amino acid metabolism, particularly in the liver 4.
  • It modulates NADP/NADPH balance, impacting numerous metabolic pathways 4.

In summary, molecular hydrogen has multifaceted interactions with cells, influencing redox status, gene expression, metabolism, and inflammatory processes through both direct and indirect mechanisms. Its ability to easily penetrate cells allows it to exert effects throughout various cellular compartments.

FAQ’s

How does molecular hydrogen act as an antioxidant?

Unlike most antioxidants, molecular hydrogen is selective, targeting only harmful free radicals while leaving beneficial ones intact. It can easily penetrate cell membranes and potentially protect against oxidative stress at the cellular level.

How is molecular hydrogen water produced?

Molecular hydrogen water is typically produced through electrolysis, where an electric current is passed through water to split it into hydrogen and oxygen. The hydrogen gas is then dissolved back into the water at high concentrations.

Does molecular hydrogen water affect gut microbiota?

Recent studies suggest that molecular hydrogen water may positively influence gut microbiota composition. Research has shown that consuming hydrogen-rich water can increase the abundance of beneficial bacteria like Bifidobacterium and reduce potentially harmful bacteria in the gut. 1

Can hydrogen water impact cellular senescence?

Emerging research indicates that molecular hydrogen may have anti-aging effects at the cellular level. Some studies have shown that hydrogen can suppress cellular senescence, which is the process by which cells stop dividing and can contribute to aging and age-related diseases 2

How does hydrogen water interact with prescription medications?

Currently, there is no evidence to suggest that hydrogen water interferes with prescription medications. However, as with any dietary supplement, it's advisable to consult with a healthcare professional before incorporating hydrogen water into your routine, especially if you're taking medications3.The neutral nature of molecular hydrogen makes significant interactions unlikely, but individual cases may vary.

Can hydrogen water influence epigenetic modifications?

Preliminary research suggests that molecular hydrogen may have epigenetic effects. Some studies have shown that hydrogen can influence DNA methylation patterns and histone modifications, potentially affecting gene expression2.This could have implications for various health conditions and aging processes, though more research is needed to fully understand these effects.

Does the production method of hydrogen water affect its therapeutic potential?

The method used to produce hydrogen water can indeed impact its therapeutic potential. Factors such as the concentration of dissolved hydrogen, the presence of contaminants, and the stability of the hydrogen in the water can all vary depending on the production technique5.Electrolysis-based methods typically produce higher concentrations of hydrogen compared to simple bubbling methods, potentially leading to greater therapeutic effects. It's important to choose hydrogen water products that use validated production methods and provide information on hydrogen concentration.